First US Cancer Patients Are Undergoing CRISPR In New Gene-Editing Trial

A CRISPR clinical trial is currently underway at the University of Pennsylvania, where researchers are testing the efficacy of gene-editing technologies in treating cancer patients.

“To date, two patients with relapsed cancers – one with multiple myeloma and one with sarcoma – have been treated as part of this trial,” wrote Penn Medicine spokesperson in an email sent to IFLScience. “Findings from this research study will be shared at an appropriate time via a medical meeting presentation or peer-reviewed publication.”

CRISPR works by targeting certain genes responsible for certain functions or traits. When found, an enzyme called Cas9 binds to the DNA, “cuts” it, and shuts off that targeted gene. Beginning last fall, the team has begun the process of removing cells from the patients’ immune systems and modifying them in the lab, before introducing them back into the patients. Hopefully, those modified cells will target and destroy cancer cells, NPR first reported. No information is available about how well the procedure is working on the two patients, but researchers plan to eventually treat 18 patients with various forms of cancer by the close of the trial in 2033.


Recommended For You

Animaytor Enterprise Personal | Studio Grade Local Videos

Animaytor Enterprise Personal | DONE-FOR-YOU Niche Explainer Videos, Local Niche Video Templates, Scripts and Voiceovers plus Graphics Creator! LOWEST One-Time Exclusive Price TODAY Only!

DocStudioFX Elite

Create, Edit, Rebrand And Share STUNNING eBooks, Magazines, White Papers And Reports With Our Secret Built-In Monetization Technology

An illustration shows the use of CRISPR to enhance CAR T cell-mediated killing of tumor cells through disruption of PD-1 protein. Targeted cells are extracted from the cancer patient, edited in the lab, and reinfused back into the body in hopes they will attack cancer cells. Meletios Verras/Shutterstock

If successful, the trial is one of many that could revolutionize how diseases are prevented and treated.

Earlier this year, concerns over the use of CRISPR were raised after Chinese researcher He Jiankui used the technology to modify the DNA of twin girls in an attempt to give them resistance to the human immunodeficiency virus (HIV) before the two were born, prompting a moratorium from the research community on such practices. This contentious research differs dramatically from the clinical trial involving cancer patients in that it was conducted on human embryos and created changes in heritable traits that could be passed down for generations to come. Rather, UPenn researchers are providing a medical treatment that only modifies the DNA of the participating individuals and, to their knowledge, would not result in potentially passing down altered genes to their children.

As NPR notes, other human trials involving CRISPR are set to begin in the US, Canada, and Europe in order to test how well it can treat a variety of diseases, including two other US-based CRISPR studies designed to treat the genetic blood disorders sickle cell disease and beta thalassemia

 [H/T: NPR]

Original Article : HERE ; This post was curated & posted using : RealSpecific

This post was curated & Posted using : RealSpecific

Thank you for taking the time to read our article.

If you enjoyed our content, we'd really appreciate some "love" with a share or two.

And ... Don't forget to have fun!


StockKosh - Gigantic Collection of Premium 35,000+ 100% Royalty Free Never Before Released Stock Gra

StockKosh is the Biggest Ever Stock Content Launch in the History of Jvzoo. Featuring 115,000+ Images, 10,000+ Vectors, 665+ Transparent PNGs, 3,100+ HD Videos, 2,500+ HQ Clipart, 1,500+ Audio Tracks, 700+ Video Backgrounds, 8,000+ Animated Graphics and

IM Checklist Volume 12: Offline Business Startup

IM Checklist Volume 12: Offline Business Startup - 18 Step by Step Checklists covering everything you need to know about setting up an offline business with Crowd Funding included. Full PLR Included

Commission Funnels LICENSE

Highly Profitable Commission Funnels You Can Copy and Paste To Generate 6+ Figures Per Month! 100% CLOUD BASED WEB APP!

Leave a Reply