Monkey Born From Frozen Prepubescent Testicle Tissue For The First Time

In a world first, sperm from a frozen sample of testicle tissue has been used to create a baby monkey, in a study that could have huge implications for young people undergoing treatment for cancer that could affect their fertility.

If replicated in humans, boys undergoing chemotherapy that could affect their ability to produce sperm could have their testicle tissue frozen, preserving it for if and when they want children themselves. Before it can be tested in humans, scientists tested it on monkeys, and a paper published in Science today announced the birth of a healthy baby Rhesus macaque, named Grady.

Importantly, Grady was born from the cryopreserved testicular tissue of a prepubescent macaque, which had not started producing sperm yet. 


Recommended PRODUCTS
  • Are you frustrated that your expensive karoke player does not let you play.
  • Download the PDF That Tells You What Teams To Bet On In The Half Time Betting Market.
  • Discover The 7 Secrets To Becoming An End-Time Prophecy Expert In 48 Hours...
  • Workouts That Anyone Can Fit Into Their Busy Schedule To Burn Fat And Build Muscle
  • Discover how to boost your goal achieving skills in 30 days, guaranteed
  • Take a trip down memory lane - to home cooked meals eaten with family.
  • Imagine 2843 Life Power Boosters At Your Fingertips
  • Need to pass a test or interview on Excel Free videos teach you Excel.
  • Easy to follow low pain exercises to get your shoulder feeling and moving great again.
  • Discover How To Add 20lbs To Your Bench Press, 15lbs To Deadlift, And 20lbs To Your Squat In 3 Months
  • System unleashes the groundbreaking secrets of the latest demolisher betting system.
  • Time and Money Saver For New Pool Room Or Bar Entrepreneurs.
  • Forces Your Body To Build New Muscle While Significantly Shedding Stubborn Belly Fat.
  • Total six packs abs reveals chiseled, granite-like six-pack in record time.
  • Clickbank Ads
     

    Adult men can choose to freeze their sperm before undertaking cancer treatment that may damage their fertility. Boys can’t produce sperm until they go through puberty, when hormonal changes increase testosterone, which kick-starts stem cells in the testes to start producing sperm. In prepubescent boys, chemotherapy or radiation therapy can kill off those cells, causing permanent infertility.

    There are clinics and fertility centers that have already started keeping frozen tissue from testicles before children start cancer treatment, in the hope that one day scientists will successfully find a way to use it to produce viable sperm. Now, with the success of Grady, researchers have shown it can be done – albeit, in primates – but this is a huge step.

    “Cancer survivors tell us that their fertility status has a really important impact on their quality of life,” senior author Dr Kyle Orwig, professor of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine (UPMC), told The Verge. “This advance is an important step toward offering young cancer patients around the world a chance at having a family in the future,” he added in a statement

    More than 300,000 children are diagnosed with cancer around the world each year, nearly 11,000 in the US alone, but cancer survival rates are now more than 80 percent, so the need for this kind of fertility assistance is increasing.

    “Previous research in non-human primates has demonstrated that sperm could be produced from autologous transplants of frozen prepubertal testicular tissue, but the ability to produce a healthy live offspring – the gold standard of any reproductive technology – has not been achieved until now,” said first author Adetunji Fayomi.

    To do this, researchers from UPMC developed a monkey model of cancer survivorship. Before starting chemo, they removed the testis of a young macaque and cryopreserved the tissue. After chemo, as the monkeys approached puberty, the other testis was removed, and the thawed frozen sample was grafted to the skin of the original monkey, along with transplanted tissue from the just-removed testis. As the monkeys entered puberty, their testosterone levels kicked in, allowing the grafted tissue to mature, and start producing sperm. 

    A year after the animals went through puberty and began producing sperm, samples were sent to the Oregon National Primate Research Center at Oregon Health and Science University, who were able to produce viable embryos transferred to host females. In April 2018, Grady was born.

    “With Grady’s birth, we were able to show proof-of-principle that we can cryopreserve prepubertal testicular tissue, and later use it to restore fertility as an adult,” Fayomi said.

    The researchers hope the next step will be a clinical trial, but there are still issues to tackle before that stage. Grady needs to be studied to see how she grows, and if there are any health concerns, and the issue of previous animal test subjects having all been castrated, whereas humans will likely have their testicles intact, needs to be addressed, amongst others. But this is a groundbreaking first step in the right direction.

    Original Article : HERE ; This post was curated & posted using : RealSpecific

     


    RELATED PRODUCTS
  • Are you frustrated that your expensive karoke player does not let you play.
  • Easy to follow low pain exercises to get your shoulder feeling and moving great again.
  • Workouts That Anyone Can Fit Into Their Busy Schedule To Burn Fat And Build Muscle
  • Download the PDF That Tells You What Teams To Bet On In The Half Time Betting Market.
  • Imagine 2843 Life Power Boosters At Your Fingertips
  • Discover The 7 Secrets To Becoming An End-Time Prophecy Expert In 48 Hours...
  • Need to pass a test or interview on Excel Free videos teach you Excel.
  • Take a trip down memory lane - to home cooked meals eaten with family.
  • Discover How To Add 20lbs To Your Bench Press, 15lbs To Deadlift, And 20lbs To Your Squat In 3 Months
  • Discover how to boost your goal achieving skills in 30 days, guaranteed
  • System unleashes the groundbreaking secrets of the latest demolisher betting system.
  • Lose body fat, build muscle, increase your strength and work capacity and have a blast.
  • A magic formula for dating for men for ultimate success with women.
  • Advanced techniques to help you lose as much fat as possible over the course of 19 days.
  • Clickbank Ads
     

    Thank you for taking the time to read our article.

    If you enjoyed our content, we'd really appreciate some "love" with a share or two.

    And ... Don't forget to have fun!

    Recommended

    Instant eCom Funnels AGENCY PRO

    Done For You eCom Product Funnels In Less Than 60 Seconds! Perfect for dropshippers who want to avoid expensive Shopify fees!

    PixlyPro Lite - Conversion and Traffic Boosting Software

    Cutting edge software creates viral marketing campaigns across multiple platforms – slashing the cost of traffic to a few cents per click New technology integrates call to action with 6 remarketing platforms, Never seen before concept Cheap, targeted tra

    Leave a Reply